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KMID : 1145520210070010022
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Journal of Radiopharmaceuticals and Molecular Probes
2021 Volume.7 No. 1 p.22 ~ p.32
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Organometallic fluorine-18 bonds in 18F-radiochemistry
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Chun Joong-Hyun
Lee Min-Ju
Jun Sung-Won
Son Jeong-Min
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Abstract
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Fluorine-18 is by far the most widely exploited radionuclide in PET (positron emission tomography) radiochemistry. The physical half-life of fluorine-18 allows for chemical manipulation within a restricted timeframe, and cyclotron-produced fluoride ion has been widely applied in aliphatic and aromatic nucleophilic radiofluorinations to produce a variety of established radiotracers. Radiotracers have become more structurally complicated to address diverse targets in physiobiological systems. There is therefore an unmet need to complement traditional C-18F bond-forming radiofluorination with new and efficient radiolabeling techniques to tackle the myriad of possible chemical environments. This review discusses recent advances in organometallic fluorine-18 bond creation in 18F-radiochemistry. Although not widely employed, new radiolabeling strategies for constructing boron-18F, silicon-18F, aluminum-18F, and other metal-18F bonds are described in view of their potential use in the development of novel radiopharmaceuticals.
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KEYWORD
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Fluorine-18, Organometallic bond, Radiolabeling, Radiopharmaceutical, PET
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